Our bone, tendon, and joint repair platforms provide a robust translational foundation for evaluating regenerative therapies, biologics, implants, and surgical interventions aimed at musculoskeletal repair. We establish clinically relevant injury models such as tendon rupture, cartilage degeneration, ligament insufficiency, and joint instability in NHPs, replicating the biomechanical and healing challenges observed in human patients. These studies incorporate surgical repair techniques, regenerative scaffolds, growth factors, stem cell–based products, and gene therapy interventions, all monitored with validated orthopedic imaging tools including MRI, CT, and micro-CT for quantitative assessment of bone and cartilage remodeling. Functional outcomes are supported by biomechanical testing, gait analysis, and pain behavior profiling, complemented by longitudinal histopathology and biomarker panels for inflammatory and regenerative processes. Acute, sub-chronic, and long-term safety endpoints are captured in parallel, ensuring that novel therapeutic modalities are evaluated for both efficacy and tolerability.

 

All work is performed under strict GLP compliance with AAALAC-accredited facilities, ensuring reproducibility and regulatory acceptance. By combining advanced imaging, precise surgical modeling, and multiparametric functional testing, our musculoskeletal platforms deliver the translational rigor required to de-risk development pipelines, support FDA and EMA regulatory filings, and accelerate the clinical application of innovative orthopedic and regenerative therapies.