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Contract Research Services

America's Premier NHP CRO.

AGI delivers specialized contract research services across pharmacology, toxicology, and translational domains. Our BSL-2 laboratories are fully equipped for viral, cellular, and molecular assays, while GLP-capable platforms support compliant execution of pharmacokinetic, toxicokinetic, and safety studies. Advanced surgical suites and telemetry-enabled monitoring systems enable precision delivery, longitudinal data capture, and organ-specific assessments in NHP models. All studies are designed to align with FDA and EMA expectations, ensuring robust datasets that withstand regulatory scrutiny and accelerate IND-enabling development.

Pharmacokinetics & Toxicology

Pharmacology & Disease Models

Surgical & Interventional Models

Ophthalmology & Orthopedics

Imaging, Data, & Analysis

Pharmacokinetics & Toxicology

PK, TK, & PD Study Execution

We conduct full-scope pharmacokinetic, toxicokinetic, and pharmacodynamic studies to support IND-enabling and early-phase drug development across diverse therapeutic programs.

Immunotoxicology & Genetic Safety

Our immunotoxicology services evaluate immune activation, cytokine profiles, and genetic safety using high-resolution in vivo and ex vivo NHP models, supporting both exploratory and regulatory development.

Dosing Route Optimization

We test multiple dosing routes—including IV, IM, SC, PO, and IN—to define optimal delivery, biodistribution, and expression profiles in NHPs, supporting therapeutic development across diverse modalities.

GLP-Compliant & Exploratory Toxicology Studies

We conduct both GLP-compliant and exploratory toxicology studies in NHPs to evaluate safety margins, identify target organ toxicity, and support regulatory submissions and IND programs.

Organ-Specific & Targeted Toxicity Assessment

Our studies map tissue-specific toxicities in NHPs using imaging, histopathology, and biomarker profiling to characterize adverse effects and de-risk therapies before human trials.

Bioanalytical Assay Development & Validation

We develop and validate custom PK, PD, and immunogenicity assays for use in NHP studies, ensuring analytical reliability and data integrity across the entire preclinical development pipeline.

Pharmacology & Disease Models

Immunopharmacology & Immunotoxicology

We conduct detailed immune profiling to assess cytokine responses, vaccine adjuvanticity, and immunotoxic effects, supporting preclinical safety and mechanism-of-action studies.

Inflammatory & Metabolism Models

Our models of chronic inflammation, obesity, insulin resistance, and NASH reflect human pathophysiology and enable translational evaluation of candidate therapeutics.

Gene & Cell Therapy Models​​

We support gene and cell therapy programs with advanced delivery platforms (AAV, LNP, viral vectors) to assess tropism, persistence, immunogenicity, and tissue-specific expression.

Discovery Pharmacology

We offer exploratory pharmacology studies to evaluate target engagement, dose-response relationships, and preliminary efficacy in behaviorally and biologically relevant systems.

Biomarker Discovery & Validation

We identify and validate fluid and tissue biomarkers through serial sampling, flow cytometry, histopathology, and multiplex immunoassays to support translational development.

Autoimmune/Rare Disease Indications

We develop and apply preclinical models for autoimmune and orphan indications, enabling immunologic and functional characterization of novel therapies in clinically relevant systems.

Surgical & Interventional Models

General & Microsurgery

We provide high-precision surgical models for preclinical research, from routine procedures to complex microsurgery, all performed by experienced veterinary surgeons.

Robotic & Minimally Invasive Procedures

We offer robotic and laparoscopic surgical models that minimize recovery time, improve animal welfare, and enhance translational relevance across a wide range of therapeutic areas and device development programs.

Interventional & Hybrid Techniques

Our hybrid surgical suites enable integrated, image-guided procedures for targeted delivery, precise vascular access, and comprehensive advanced therapeutic evaluation in preclinical models.

Neurosurgery & Targeted CNS Delivery

Our CNS platforms enable direct delivery to brain and spinal targets, supporting gene therapy, biologics, and device testing with exacting accuracy and reproducibility across preclinical studies.

Structural Heart & Cardiovascular Models

We model complex cardiovascular conditions in NHPs to evaluate novel interventions under clinically relevant hemodynamic loads, generating data to inform translational development.

Implantable Devices & Surgical Tool Testing

We evaluate prototype and commercial devices in NHPs under real-world use scenarios, generating actionable data on safety, performance, durability, and usability to guide clinical translation.

Ophthalmology & Orthopedics

Retinal & Intraocular Delivery

We support targeted ocular delivery with refined techniques for subretinal, intravitreal, and suprachoroidal injection in NHPs, enabling preclinical testing of AAV vectors, biologics, and novel therapeutics.

Intraocular Devices & Imaging

Our team evaluates implantable ocular devices and advanced high-resolution imaging tools for safety, durability, and performance under diverse, clinically relevant conditions.

Ocular Safety & Gene Therapy Models

We develop and validate models of ocular inflammation, degeneration, and gene transfer to assess safety, expression kinetics, immune responses, and long-term efficacy across treatment platforms.

Bone, Tendon, & Joint Repair

Research Models

We offer repair models for tendon rupture, cartilage damage, and joint instability, incorporating surgical intervention, regenerative scaffolds, and biomechanical testing.

Spine & Vertebral Disc Intervention Models

Our capabilities include cervical and lumbar disc access, intervertebral injections, and implant studies to support spinal therapeutics and device testing, with imaging and surgical support.

Efficacy Testing for Regenerative Therapies

We evaluate regenerative candidates using quantitative imaging, tissue histology, and functional endpoints in NHP models of musculoskeletal and ocular repair to support translational development.

Imaging, Data, & Analysis

Echocardiography & PV Loops

We perform functional cardiac assessments in NHPs to evaluate systolic performance, diastolic relaxation, and vascular responsiveness, supporting cardiovascular safety and efficacy.

ECG & Respiratory Measurements

Our telemetry-enabled platforms capture real-time cardiac and pulmonary data, enabling continuous monitoring during dosing, challenge, and recovery phases in preclinical studies.

 MRI, CT, PET & X-Ray

We leverage multimodal imaging to visualize biodistribution, track cellular therapies, and quantify tissue-level changes across preclinical models with translational relevance.

Quantitative Image Analysis & Custom Reporting

Our imaging specialists deliver precise, metric-driven data outputs—paired with tailored reporting formats that align with client protocols and regulatory submission requirements.

Pathology, Histology & Clinical Path Chemistry

Comprehensive pathology services include gross necropsy, histological scoring, and serum chemistry panels to evaluate organ integrity and systemic responses to candidate therapies.

Digital Data Capture & Real-Time Telemetry Integration

We integrate physiological data streams with digital lab platforms for telemetry capture, automated alerts, synchronized event tracking, and centralized monitoring across all phases of complex studies.

Automated Pipetting System
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