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AAALAC-accreditedUSDA-licensedOLAW-assuredPreclinical research & animal resources for global programs +1 (843) 589-5190 info@alphagenesisinc.com
Research animal retirement and lifetime care, now available through Alpha Genesis. Professionally managed lifetime care for retired research primates, with expert social reintroduction into stable outdoor groups led by veterinary staff deeply experienced in laboratory-animal medicine.
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Program
Alpha Genesis runs the early in vivo work that establishes proof of concept and selects a candidate. Programs test the pharmacological hypothesis in rodent and nonhuman primate models and generate the efficacy, mechanism and exposure data that support the decision to advance.
Discovery and pharmacology programs establish whether a compound produces the intended effect in a living system and at what exposure. Studies begin with efficacy in a relevant disease model and pair the response with mechanism and target-engagement readouts that confirm the compound is acting as expected.
As the data accumulate, dose-ranging and tolerability work define the useful exposure range, and comparative results across candidates inform the selection of a lead. Bioanalysis and biomarker endpoints run alongside the in vivo work so that each result can be interpreted in context.
What this program covers
The in vivo studies, the bioanalysis and the biomarker work all sit inside Alpha Genesis. Each part of the program is planned and run by the same team.
Pharmacology studies in rodent and nonhuman primate models under one program.
Established disease and challenge models that test the pharmacological hypothesis.
Readouts that confirm the compound reaches and acts on the intended target.
Graded dose levels that define the exposure and effect relationship.
Clinical observation, body weight and in-life endpoints that characterize tolerability.
Exposure sampling paired with pharmacodynamic endpoints to link dose to effect.
Molecular, cellular and soluble biomarkers that support interpretation of the response.
Comparative in vivo data that inform the choice of a lead candidate.
Scheduled necropsy and tissue collection for downstream pathology and molecular analysis.
Rodent through nonhuman primate
Early pharmacology work often starts in rodent models and moves into nonhuman primates as a program matures and the candidate is defined. Both stages run within one organization, so the models, endpoints and bioanalysis stay consistent as the work advances.
Discuss your program
Tell us about the compound and the effect you are trying to establish. Alpha Genesis can design the pharmacology studies, run the rodent and nonhuman primate work and generate the data that supports candidate selection.