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AAALAC-accreditedUSDA-licensedOLAW-assuredPreclinical research & animal resources for global programs +1 (843) 589-5190 info@alphagenesisinc.com
Research animal retirement and lifetime care, now available through Alpha Genesis. Professionally managed lifetime care for retired research primates, with expert social reintroduction into stable outdoor groups led by veterinary staff deeply experienced in laboratory-animal medicine.
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Program
This program measures how much drug reaches the body and where it goes, then relates that exposure to effect. Alpha Genesis runs the pharmacokinetics, biodistribution and bioanalysis in rodent and nonhuman primate models under one program.
A dose only matters through the exposure it produces. We measure the concentration a molecule reaches in blood and tissue over time, then relate that exposure to the pharmacodynamic response it drives.
The result is a quantitative account of how the molecule behaves in the body, which defines the doses and schedules that carry the program into safety and IND-enabling work.
What this program covers
Pharmacokinetics, biodistribution and the bioanalytical readouts that quantify them all sit inside Alpha Genesis and support one connected line of work.
Single and repeat-dose pharmacokinetics in rodent and nonhuman primate models, with defined absorption, distribution and clearance parameters.
Models that link measured exposure to pharmacodynamic response and support dose and schedule selection.
Tissue distribution and clearance across dose levels and time points, including target and clearance organs.
Sampling strategies that resolve the concentration-time profile without compromising animal welfare or study integrity.
Absolute and relative bioavailability across intravenous, subcutaneous, oral and other routes of administration.
Quantitation of small molecules and peptides by LC-MS/MS, with method development and validation.
Quantitation of pharmacodynamic and mechanistic biomarkers that report target engagement and effect.
Ligand-binding assays for large molecules, anti-drug antibodies and cytokine and immune readouts.
Analysis that relates exposure to efficacy and safety endpoints across the studied dose range.
Why it matters
Exposure-response data define the doses and schedules that a safety study should test and the margins those studies need to demonstrate. Without that grounding, dose selection rests on assumption rather than measured behavior.
The pharmacokinetic and biodistribution readouts generated here feed directly into Safety & Toxicology and into the IND-enabling development package, where the same exposure measures anchor the toxicokinetic and margin analysis a submission requires.
Discuss your program
Tell us what you are developing and the exposure and effect questions you need to answer. We will define the pharmacokinetic, biodistribution and bioanalytical work that resolves them.